Molecular evolution of GYPC: Evidence for recent structural innovation and positive selection in humans In Press at Molecular Biology and Evolution
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Molecular Evolution of GYPC: Evidence for Recent Structural Innovation and Positive Selection in Humans
GYPC encodes two erythrocyte surface sialoglycoproteins in humans, glycophorin C and glycophorin D (GPC and GPD), via initiation of translation at two start codons on a single transcript. The malaria-causing parasite Plasmodium falciparum uses GPC as a means of invasion into the human red blood cell. Here, we examine the molecular evolution of GYPC among the Hominoidea (Greater and Lesser Apes)...
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